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Effects of an in-frame deletion of the 6k gene locus from the genome of Ross River virus

Taylor, Adam; Melton, Julian; Herrero, Lara; Thaa, Bastian; Karo-Astover, Liis; Gage, Peter; Nelson, Michelle; Sheng, Kuo-Ching; Lidbury, Brett; Ewart, Gary; McInerney, Gerald M.; Merits, Andres; Mahalingam, Surendran

Description

The alphaviral 6k gene region encodes the two structural proteins 6K protein and, due to a ribosomal frameshift event, the transframe protein (TF). Here, we characterized the role of the 6k proteins in the arthritogenic alphavirus Ross River virus (RRV) in infected cells and in mice, using a novel 6k in-frame deletion mutant. Comprehensive microscopic analysis revealed that the 6k proteins were predominantly localized at the endoplasmic reticulum of RRV-infected cells. RRV virions that lack the...[Show more]

CollectionsANU Research Publications
Date published: 2016
Type: Journal article
URI: http://hdl.handle.net/1885/152339
Source: Journal of Virology
DOI: 10.1128/JVI.03192-15
Access Rights: Open Access

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