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Hepatocytes Traffic and Export Hepatitis B Virus Basolaterally by Polarity-Dependent Mechanisms

Bhat, Purnima; Snooks, Michelle J; Anderson, David A


Viruses commonly utilize the cellular trafficking machinery of polarized cells to effect viral export. Hepatocytes are polarized in vivo, but most in vitro hepatocyte models are either nonpolarized or have morphology unsuitable for the study of viral export. Here, we investigate the mechanisms of trafficking and export for the hepadnaviruses hepatitis B virus (HBV) and duck hepatitis B virus (DHBV) in polarized hepatocyte-derived cell lines and primary duck hepatocytes. DHBV export, but not...[Show more]

CollectionsANU Research Publications
Date published: 2011
Type: Journal article
Source: Journal of Virology
DOI: 10.1128/JVI.05344-11
Access Rights: Open Access


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