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Phosphorothioate backbone modifications of nucleotide-based drugs are potent platelet activators

Flierl, Ulrike; Nero, Tracy L.; Lim, Bock; Arthur, JF; Yao, Yu; Jung, Stephanie M.; Gitz, E.; Pollitt, Alice Y.; Zaldivia, Maria T.K; Jandrot-Perrus, Martine; Gardiner, Elizabeth


Nucleotide-based drug candidates such as antisense oligonucleotides, aptamers, immunoreceptor-activating nucleotides, or (anti)microRNAs hold great therapeutic promise for many human diseases. Phosphorothioate (PS) backbone modification of nucleotide-based drugs is common practice to protect these promising drug candidates from rapid degradation by plasma and intracellular nucleases. Effects of the changes in physicochemical properties associated with PS modification on platelets have not been...[Show more]

CollectionsANU Research Publications
Date published: 2015
Type: Journal article
Source: Journal of Experimental Medicine
DOI: 10.1084/jem.20140391
Access Rights: Open Access


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