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Cathepsin B modulates lysosomal biogenesis and host defense against Francisella novicida infection

Qi, Xiaopeng; Man, Si Ming; Malireddi, R.K. Subbarao; Karki, Rajendra; Lupfer, Christopher; Gurung, Prajwal; Neale, Geoffrey; Guy, Clifford S; Lamkanfi, Mohamed; Kanneganti, Thirumala-Devi

Description

Lysosomal cathepsins regulate an exquisite range of biological functions, and their deregulation is associated with inflammatory, metabolic, and degenerative diseases in humans. In this study, we identified a key cell-intrinsic role for cathepsin B as a negative feedback regulator of lysosomal biogenesis and autophagy. Mice and macrophages lacking cathepsin B activity had increased resistance to the cytosolic bacterial pathogen Francisella novicida. Genetic deletion or pharmacological...[Show more]

CollectionsANU Research Publications
Date published: 2016
Type: Journal article
URI: http://hdl.handle.net/1885/152318
Source: Journal of Experimental Medicine
DOI: 10.1084/jem.20151938
Access Rights: Open Access

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