A DOCK8-WIP-WASp complex links T cell receptors to the actin cytoskeleton
Wiskott-Aldrich syndrome (WAS) is associated with mutations in the WAS protein (WASp), which plays a critical role in the initiation of T cell receptor-driven (TCR-driven) actin polymerization. The clinical phenotype of WAS includes susceptibility to infection, allergy, autoimmunity, and malignancy and overlaps with the symptoms of dedicator of cytokinesis 8 (DOCK8) deficiency, suggesting that the 2 syndromes share common pathogenic mechanisms. Here, we demonstrated that the WASpinteracting...[Show more]
|Collections||ANU Research Publications|
|Source:||Journal of Clinical Investigation|
|01_Janssen_A_DOCK8-WIP-WASp_complex_links_2016.pdf||3.65 MB||Adobe PDF|
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