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A DOCK8-WIP-WASp complex links T cell receptors to the actin cytoskeleton

Janssen, Erin; Tohme, Mira; Hedayat, Mona; Leick, Marion; Kumari, Sudha; Ramesh, Narayanaswamy; Massaad, Michel J; Ullas, Sumana; Azcutia, Veronica; Goodnow, Christopher; Randall, Katrina; Qiao, Qi

Description

Wiskott-Aldrich syndrome (WAS) is associated with mutations in the WAS protein (WASp), which plays a critical role in the initiation of T cell receptor-driven (TCR-driven) actin polymerization. The clinical phenotype of WAS includes susceptibility to infection, allergy, autoimmunity, and malignancy and overlaps with the symptoms of dedicator of cytokinesis 8 (DOCK8) deficiency, suggesting that the 2 syndromes share common pathogenic mechanisms. Here, we demonstrated that the WASpinteracting...[Show more]

CollectionsANU Research Publications
Date published: 2016
Type: Journal article
URI: http://hdl.handle.net/1885/152309
Source: Journal of Clinical Investigation
DOI: 10.1172/JCI85774

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