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The Import of Proteins into the Mitochondrion of Toxoplasma gondii

van Dooren, Giel; Yeoh, Lee M.; Striepen, Boris; McFadden, Geoffrey I

Description

Outside of well characterized model eukaryotes, relatively little is known about the translocons that transport proteins across the two membranes that surround the mitochondrion. Apicomplexans are a phylum of intracellular parasites that cause major diseases in humans and animals and are evolutionarily distant from model eukaryotes such as yeast. Apicomplexans harbor a mitochondrion that is essential for parasite survival and is a validated drug target. Here, we demonstrate that the...[Show more]

CollectionsANU Research Publications
Date published: 2016
Type: Journal article
URI: http://hdl.handle.net/1885/152304
Source: Journal of Biological Chemistry
DOI: 10.1074/jbc.M116.725069
Access Rights: Open Access

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