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CHD4 Is a Peripheral Component of the Nucleosome Remodeling and Deacetylase Complex

Low, Jason; Webb, Sarah; Silva, Ana; Saathoff, Hinnerk; Ryan, Daniel; Torrado, Mario; Brofelth, Mattias; Parker, Benjamin; Shepherd, Nicholas; Mackay, Joel P.

Description

Chromatin remodeling enzymes act to dynamically regulate gene accessibility. In many cases, these enzymes function as large multicomponent complexes that in general comprise a central ATP-dependent Snf2 family helicase that is decorated with a variable number of regulatory subunits. The nucleosome remodeling and deacetylase (NuRD) complex, which is essential for normal development in higher organisms, is one such macromolecular machine. The NuRD complex comprises ∼10 subunits, including the...[Show more]

CollectionsANU Research Publications
Date published: 2016
Type: Journal article
URI: http://hdl.handle.net/1885/152303
Source: Journal of Biological Chemistry
DOI: 10.1074/jbc.M115.707018
Access Rights: Open Access

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