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Temporal Gene Expression in the Hippocampus and Peripheral Organs to Endotoxin-Induced Systemic Inflammatory Response in Caspase-1-Deficient Mice

Mastronardi, Claudio Alberto; Paz-Filho, Gilberto; Zanoni, Martina; Molano-González, Nicolas; Arcos-Burgos, Mauricio; Licinio, Julio; Wong, Ma-Li


OBJECTIVES Caspase-1 (casp1), a key protease involved in the systemic inflammatory response syndrome (SIRS), controls the brain expression of a set of eight genes: Nos2 and Ptgs2 (nitric oxide synthase 2 and prostaglandin-endoperoxide synthase 2, two inducible enzymes), Cxcl1 and Cxcl10 (C-X-C motif chemokine ligand 1 and ligand 10), Tgtp and Gbp2 (T cell-specific GTPase 1 and guanylate-binding protein 2, two GTPases), Adamts1 (a disintegrin-like and metallopeptidase with thrombospondin type 1...[Show more]

CollectionsANU Research Publications
Date published: 2015-04
Type: Journal article
Source: Neuroimmunomodulation
DOI: 10.1159/000368310


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