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Transcriptomic and proteomic analyses reveal key innate immune signatures in the host response to the gastrointestinal pathogen Campylobacter concisus

Kaakoush, Nadeem; Deshpande, Nandan P; Man, Si Ming; Burgos-Portugal, Jose A; Khattak, Faisal A; Raftery, Mark; Wilkins, Marc R.; Mitchell, Hazel

Description

Pathogenic species within the genus Campylobacter are responsible for a considerable burden on global health. Campylobacter concisus is an emergent pathogen that plays a role in acute and chronic gastrointestinal disease. Despite ongoing research on Campylobacter virulence mechanisms, little is known regarding the immunological profile of the host response to Campylobacter infection. In this study, we describe a comprehensive global profile of innate immune responses to C. concisus infection in...[Show more]

CollectionsANU Research Publications
Date published: 2015
Type: Journal article
URI: http://hdl.handle.net/1885/152284
Source: Infection and Immunity
DOI: 10.1128/IAI.03012-14
Access Rights: Open Access

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