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SadA, a trimeric autotransporter from Salmonella enterica serovar Typhimurium, can promote biofilm formation and provides limited protection against infection

Raghunathan, Dhaarini; Wells, Timothy J; Morris, Faye C; Shaw, Robert K.; Bobat, Saeeda; Peters, Sarah E.; Paterson, Gavin K.; Tveen-Jensen, Karina; Leyton, Denisse; Blair, Jessica M. A.; Browning, Douglas F.


Salmonella enterica is a major cause of morbidity worldwide and mortality in children and immunocompromised individuals in sub-Saharan Africa. Outer membrane proteins of Salmonella are of significance because they are at the interface between the pathogen and the host, they can contribute to adherence, colonization, and virulence, and they are frequently targets of antibody-mediated immunity. In this study, the properties of SadA, a purported trimeric autotransporter adhesin of Salmonella...[Show more]

CollectionsANU Research Publications
Date published: 2011
Type: Journal article
Source: Infection and Immunity
DOI: 10.1128/IAI.05592-11
Access Rights: Open Access


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