Directed evolution of an organophosphate hydrolase : methyl parathion hydrolase
Organophosphates (OPs) are the most common pesticides used in agriculture. Although they can be broken down in nature, OPs pose a severe health hazard to human due to their inhibitory effect on acetylcholine, a major enzyme in nervous transmission. Therefore, detoxification of water and soil contaminated by OPs is important. One way of achieving this is by bioremediation of sites with OP-degrading enzymes. One such enzyme is methyl parathion hydrolase (MPH) isolated from Pseudomonas sp. WBC-3....[Show more]
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