Longitudinal volumetry and shape analysis of the striatum in a cohort with leukoaraiosis : a pilot study
Background: Diffuse white matter changes (or 'leukoaraiosis') on brain MRI are a common finding, particularly in the elderly, and are linked to cognitive impairment, gait problems, depression and transition to disability. The areas of the brain that are affected by leukoaraiosis have the potential to disrupt fronto-striatal brain circuits that govern many cognitive functions, but no studies have looked at the striatum in this group - studies in a number of neurodegenerative diseases utilising...[Show more]
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