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Roles for Islet Heparan Sulfate and heparanase in Islet transplantation

Choong, Fui Jiun

Description

Previously, it has been shown that islets are surrounded by a continuous basement membrane (BM) containing perlecan, a heparan sulfate proteoglycans (HSPGs). Islets also express extraordinarily high levels of HS, which acts as an antioxidant and is critical for beta cell survival. Islet HS is lost following islet isolation. The onset of Type 1 diabetes in the NOD mice correlated with the production of catalytic active heparanase, an HS-degrading endoglycosidase by the insulitis mononuclear...[Show more]

CollectionsOpen Access Theses
Date published: 2013
Type: Thesis (PhD)
URI: http://hdl.handle.net/1885/151650
DOI: 10.25911/5d5152f99bb53
Access Rights: Open Access

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