Roles for Islet Heparan Sulfate and heparanase in Islet transplantation
Previously, it has been shown that islets are surrounded by a continuous basement membrane (BM) containing perlecan, a heparan sulfate proteoglycans (HSPGs). Islets also express extraordinarily high levels of HS, which acts as an antioxidant and is critical for beta cell survival. Islet HS is lost following islet isolation. The onset of Type 1 diabetes in the NOD mice correlated with the production of catalytic active heparanase, an HS-degrading endoglycosidase by the insulitis mononuclear...[Show more]
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