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Synthetic Approaches to the Macrocyclic Natural Product Tripartilactam

Vo, Yen Thi Hoang

Description

In 2012 Oh and co-workers reported the isolation of the tricyclic macrolactam tripartilactam from a Streptomyces sp. found in the brood ball of the dung bettle Copris tripartitus. The compound proved to be a moderate inhibitor of sodium/potasium ATPase. The unique and rather complex structure embodies a cyclobutane fused, on its opposing faces, to both an 8- and an 18-membered ring. These architecturally novel features prompted the author to pursue a total synthesis of it. Chapter One provides...[Show more]

CollectionsOpen Access Theses
Date published: 2016
Type: Thesis (PhD)
URI: http://hdl.handle.net/1885/151611
DOI: 10.25911/5d51538e3f34d
Access Rights: Open Access

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