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The influence of host genetics on erythrocytes and malaria infection: is there therapeutic potential?

Lelliott, Patrick M.; McMorran, Brendan J.; Foote, Simon J.; Burgio, Gaetan

Description

As parasites, Plasmodium species depend upon their host for survival. During the blood stage of their life-cycle parasites invade and reside within erythrocytes, commandeering host proteins and resources towards their own ends, and dramatically transforming the host cell. Parasites aptly avoid immune detection by minimizing the exposure of parasite proteins and removing themselves from circulation through cytoadherence. Erythrocytic disorders brought on by host genetic mutations can interfere...[Show more]

CollectionsANU Research Publications
Date published: 2015-07-29
Type: Journal article
URI: http://dx.doi.org/10.1186/s12936-015-0809-x
http://hdl.handle.net/1885/15161
Source: Malaria Journal
DOI: 10.1186/s12936-015-0809-x

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