Role of IL-3 receptor alpha isoforms and microRNAs in IL-3-driven myeloid differentiation
Blood cell formation involves proliferation of hematopoietic stem cells coupled with progressive maturation and lineage commitment. There is a critical requirement to maintain stem cell numbers by self-renewal. The mechanisms which control both differentiation and the balance between self-renewal and differentiation are poorly understood. The focus of this thesis is on myeloid differentiation. Four myeloid differentiation pathways have been recognized: (1) steady state myeloid differentiation,...[Show more]
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