Identifying the in vitro interactions between the skeletal muscle ryanodine receptor, triadin and calsequestrin
Excitation-contraction coupling (EC coupling) is a process linking depolarization of a muscle fibre membrane with eventual mechanical contraction of that fibre. Key in this process is calcium release into the muscle fibre cytoplasm from an intracellular store (sarcoplasmic reticulum, SR) via a ligand gated calcium channel, the ryanodine receptor (RyR). Numerous proteins engage in RyR regulation to ensure healthy calcium release during EC coupling. One such protein is triadin, which binds both...[Show more]
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