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A structural investigation of mechanism in human glutathione transferase omega 1

Brock, Joseph Sydney

Description

This thesis investigates the structural details of catalysis associated with the human enzyme, Glutathione Transferase Omega 1 (hGSTO1-1), a member of the most recently discovered class of Glutathione Transferase. The human genome contains two Omega class genes (hGSTO1 and 2) and their transcribed products have been found at varied levels within almost every tissue of the human body. The crystal structure of hGSTO1-1 displays a distinguishing cysteine residue in the active site, a feature that...[Show more]

CollectionsOpen Access Theses
Type: Thesis (PhD)
URI: http://hdl.handle.net/1885/151494

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