Skip navigation
Skip navigation

Evolution of X chromosome inactivation in therian mammals

Al Nadaf, Shafagh

Description

In therian (eutherian and marsupial) mammals, X gene dosage between XY males and XX females is equalized by transcriptional silencing of one X chromosome in the somatic cells of females; a process called X chromosome inactivation (XCI). There are fundamental differences between the random, stable XCI in eutherians, and the paternal and partial system in marsupials, which can be exploited to dissect the mechanisms and evolution of XCI. A striking molecular difference is the involvement of DNA...[Show more]

CollectionsOpen Access Theses
Type: Thesis (PhD)
URI: http://hdl.handle.net/1885/151486

Download

File Description SizeFormat Image
b28799628_Al Nadaf_Shafagh.pdf28.27 MBAdobe PDFThumbnail


Items in Open Research are protected by copyright, with all rights reserved, unless otherwise indicated.

Updated:  22 January 2019/ Responsible Officer:  University Librarian/ Page Contact:  Library Systems & Web Coordinator