Evolution of X chromosome inactivation in therian mammals
In therian (eutherian and marsupial) mammals, X gene dosage between XY males and XX females is equalized by transcriptional silencing of one X chromosome in the somatic cells of females; a process called X chromosome inactivation (XCI). There are fundamental differences between the random, stable XCI in eutherians, and the paternal and partial system in marsupials, which can be exploited to dissect the mechanisms and evolution of XCI. A striking molecular difference is the involvement of DNA...[Show more]
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