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Evolution of X chromosome inactivation in therian mammals

Al Nadaf, Shafagh


In therian (eutherian and marsupial) mammals, X gene dosage between XY males and XX females is equalized by transcriptional silencing of one X chromosome in the somatic cells of females; a process called X chromosome inactivation (XCI). There are fundamental differences between the random, stable XCI in eutherians, and the paternal and partial system in marsupials, which can be exploited to dissect the mechanisms and evolution of XCI. A striking molecular difference is the involvement of DNA...[Show more]

CollectionsOpen Access Theses
Date published: 2011
Type: Thesis (PhD)
DOI: 10.25911/5d515689c35e5
Access Rights: Open Access


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