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The role of fatty acid signalling in Islet Beta-cell adaptation to normal pregnancy

Kim, Jee-Hye

Description

Hyperinsulinaemia has an important role in normal pregnancy by mediating the process of facilitated anabolism in early pregnancy and compensating for insulin resistance in late pregnancy. However, the mechanisms affecting islet {u03B2}-cells that underlie the hyperinsulinaemia of late pregnancy remain poorly understood. There is very good evidence that lactogenic hormones are involved, but the role of lipid signalling processes has been minimally investigated. As (i) pregnancy is associated...[Show more]

CollectionsOpen Access Theses
Type: Thesis (PhD)
URI: http://hdl.handle.net/1885/151456

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