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The many facets of heparanase : not just an extracellular matrix-degrading enzyme

Yi, Qing He


Heparanase is an endo-{u03B2}-glucuronidase that cleaves heparan sulfate and facilitates the passage of migrating cells through extracellular matrices (ECM), particularly basement membranes, as well as releasing heparan sulfate-bound growth factors from the ECM, whereby the released growth factors also aid wound healing and angiogenesis. Under normal physiological conditions heparanase aids the passage of leukocytes through subendothelial basement membranes and entry into sites of...[Show more]

CollectionsOpen Access Theses
Date published: 2010
Type: Thesis (PhD)
DOI: 10.25911/5d5157b501a28
Access Rights: Open Access


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