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The many facets of heparanase : not just an extracellular matrix-degrading enzyme

Yi, Qing He

Description

Heparanase is an endo-{u03B2}-glucuronidase that cleaves heparan sulfate and facilitates the passage of migrating cells through extracellular matrices (ECM), particularly basement membranes, as well as releasing heparan sulfate-bound growth factors from the ECM, whereby the released growth factors also aid wound healing and angiogenesis. Under normal physiological conditions heparanase aids the passage of leukocytes through subendothelial basement membranes and entry into sites of...[Show more]

CollectionsOpen Access Theses
Type: Thesis (PhD)
URI: http://hdl.handle.net/1885/151431

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