Riboflavin utilisation by the malaria parasite, Plasmodium falciparum, as a target for novel antimalarials
The intraerythrocytic malaria parasite Plasmodium falciparum requires an external supply of several essential nutrients, including riboflavin (vitamin B2). In this study, riboflavin-accumulation assays were used to characterise riboflavin transport in the infected erythrocyte and isolated parasite. HPLC analysis confirmed that, once inside the parasite, riboflavin is metabolised into the important coenzymes, FMN and FAD via a similar ATP-dependent pathway as found in other organisms. ...[Show more]
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