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Riboflavin utilisation by the malaria parasite, Plasmodium falciparum, as a target for novel antimalarials

Easton, Kylie Jade

Description

The intraerythrocytic malaria parasite Plasmodium falciparum requires an external supply of several essential nutrients, including riboflavin (vitamin B2). In this study, riboflavin-accumulation assays were used to characterise riboflavin transport in the infected erythrocyte and isolated parasite. HPLC analysis confirmed that, once inside the parasite, riboflavin is metabolised into the important coenzymes, FMN and FAD via a similar ATP-dependent pathway as found in other organisms. ...[Show more]

CollectionsOpen Access Theses
Date published: 2012
Type: Thesis (PhD)
URI: http://hdl.handle.net/1885/151404
DOI: 10.25911/5d515879c0ab9
Access Rights: Open Access

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