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Analysis of Heparanase expression in human natural killer cells

Yee, Dean Yang


Natural Killer (NK) cells are cells of the innate immune system important for tumour and viral clearance. Lack of functional human NK cells results in severe and recurrent viral infections in humans. Migration of NK cells requires movement through the extracellular matrix (ECM) and basement membrane (BM). The ECM and BM are structural scaffolds which provide shape and support to cells and tissues. Migration to target sites requires the degradation of the ECM and BM. Heparanase (HPSE) is a...[Show more]

CollectionsOpen Access Theses
Type: Thesis (PhD)


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