Skip navigation
Skip navigation

Synthetic studies towards the pyrrolo [2,1-c][1,4] benzodiazepine natural products

Lu, Belinda


The work detailed in this thesis describes the development of a suitable synthetic strategy for the synthesis of pyrrolo[2,1-c][1,4]benzodiazepine (PBD) natural products such as anthramycin (1), porothramycin (2) and sibiromycin (3) - antitumour antibiotics which are capable of covalently binding to DNA and exhibit potent in vitro and in vivo cytotoxicity. The synthetic sequence involved introduction of the key stereocentre by asymmetric alkylation and construction of the C-ring dihydropyrrole...[Show more]

CollectionsOpen Access Theses
Date published: 2012
Type: Thesis (PhD)
DOI: 10.25911/5d514b165768a
Access Rights: Open Access


File Description SizeFormat Image
b30880646-Lu_B.pdf64.61 MBAdobe PDFThumbnail

Items in Open Research are protected by copyright, with all rights reserved, unless otherwise indicated.

Updated:  19 May 2020/ Responsible Officer:  University Librarian/ Page Contact:  Library Systems & Web Coordinator