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Estimation of the methylation pattern distribution from deep sequencing data

Lin, Peijie; Forêt, Sylvain; Wilson, Susan R.; Burden, Conrad J

Description

BACKGROUND: Bisulphite sequencing enables the detection of cytosine methylation. The sequence of the methylation states of cytosines on any given read forms a methylation pattern that carries substantially more information than merely studying the average methylation level at individual positions. In order to understand better the complexity of DNA methylation landscapes in biological samples, it is important to study the diversity of these methylation patterns. However, the...[Show more]

CollectionsANU Research Publications
Date published: 2015-05-06
Type: Journal article
URI: http://dx.doi.org/10.1186/s12859-015-0600-6
http://hdl.handle.net/1885/15132
Source: BMC Bioinformatics
DOI: 10.1186/s12859-015-0600-6

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