Consecutive gold[I]-catalysed cyclisation reactions leading to polyfused heterocycles of agrochemical relevance
Variolin B, a marine natural product isolated from the Antarctic sponge Kirkpatrickia variolosa, possesses a rare heterocyclic framework and is a potent CDK inhibitor. Such properties have prompted the industry partner associated with this project, namely the German chemical commodities company BASF, to select this compound as a lead for the development of new agrochemicals. This thesis details the development of new synthetic methods specifically designed to produce complex heterocyclic...[Show more]
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