Evaluation of mucosal T cell immunity following HIV-1 prime-boost immunization
Vaccination is one of the most important contributions to human health and has produced a dramatic reduction in infectious disease deaths over the last 100 years. However, there is still no successful vaccine for HIV-1 that provides full protection against infection. Because HIV-1 primarily infects the mucosae, there is strong opinion that more effective mucosal HIV-1 vaccines eliciting robust immunity at mucosal sites will be a key requirement for a successful vaccine. This thesis evaluates...[Show more]
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