A structure-function analysis of a Rho GTPase exchange factor (GEF)-GTPase activating protein (GAP) interaction
Cytokinesis is the final stage of cell division where major rearrangements of the cytoskeleton occur that result in the formation and constriction of a contractile ring at the equator of the cell. The GTPase Rho is essential for cytokinesis and it is the role of the Rho GTPase Exchange Factor (GEF) Pbl to stimulate the accumulation of an equatorial band of active Rho. Accumulation of Pbl at the midzone requires an interaction with the GTPase Activating Protein (GAP) Tum, which forms a...[Show more]
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