Gene duplication is a major mechanism for the origin of new genes. Subsequent function divergence and acquisition of new regulatory elements is the necessary step for survival of a newly duplicated gene. However, despite of existence of several models, it remains unclear how paralogs evolve after the duplication and develop new functions. An example of evolution by gene duplication is PRNP, coding for prion protein (PrP), and its downstream duplicate, PRND, coding for doppel (Dpl). Recent...[Show more]
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