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Investigating binding affinity with and sequence recognition by peptidylglycine a-amidating monooxygenase

Morris, Kelly Maree


This thesis presents studies conducted to elucidate structural features of substrates and inhibitors of the enzyme peptidylglycine alpha-amidating monooxygenase (PAM) that may be important for drug design. Given the focus on applicability to drug design, studies focussed on subtypes of PAM from human cancer cell lines. Chapter 1 of this Thesis describes the development of a cultured cell assay suitable for monitoring PAM activity from human carcinomas and quantifying enzyme inhibition. These...[Show more]

CollectionsOpen Access Theses
Date published: 2014
Type: Thesis (PhD)
DOI: 10.25911/5d5e75c43e716
Access Rights: Open Access


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