Investigating binding affinity with and sequence recognition by peptidylglycine a-amidating monooxygenase
This thesis presents studies conducted to elucidate structural features of substrates and inhibitors of the enzyme peptidylglycine alpha-amidating monooxygenase (PAM) that may be important for drug design. Given the focus on applicability to drug design, studies focussed on subtypes of PAM from human cancer cell lines. Chapter 1 of this Thesis describes the development of a cultured cell assay suitable for monitoring PAM activity from human carcinomas and quantifying enzyme inhibition. These...[Show more]
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