Effective regulation of peptide hormones
In the work described in this thesis, peptidylglycine a-amidating monooxygenase (PAM) was extracted from human H889 and DMS53 small cell lung cancer (SCLC) cells, PC-3 prostate cancer cells and SW1783 glioblastoma cells. Optimization of PAM assay conditions was carried out to maximize PAM activity. The extracted enzymes and optimized assay conditions provided a platform to assess substrate and inhibitor kinetic parameters and to compare the enzyme specificities of PAM from different human...[Show more]
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