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Directed evolution - improving enzyme properties

Mohd Hashim, Amalia


Although enzymes are the product of millions of years of natural evolution, their properties are frequently far from what is desired by biochemists. Directed evolution has long been used to improve protein properties: stability, expression, solubility, enantioselectivity, activity, and specificity as well as to dissect the relationship between protein structure and function. It mimics natural evolution as proposed by Darwin, in which large number of mutations are introduced randomly over the...[Show more]

CollectionsOpen Access Theses
Date published: 2011
Type: Thesis (PhD)
DOI: 10.25911/5d5e77aa2840d
Access Rights: Open Access


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