Synthesis of novel compounds for the study of biomolecules using NMR spectroscopy
This thesis presents an investigation into the synthesis of compounds viz., bifunctional chelators that could be used as lanthanide shift reagents and fluorinated amino acids that could be used as probes in the study of biomolecules using nuclear magnetic resonance spectroscopy. Initially, syntheses of acyclic multidentate ligands like DTPA that could function as lanthanide shift reagents were investigated. A DTPA derivative with a cysteine side arm that could bind to biomolecules via a...[Show more]
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