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Adrenergic neuromodulation of transmitter release in rat neocortex

Choy, Julian Min Chiang

Description

Presynaptic Ca{u00B2}{u207A} stores modulate transmitter release via presynaptic metabotropic glutamate receptors (group I). I hypothesized that presynaptic {u03B1}1-adrenoreceptors ({u03B1}1-ARs) have the potential to cause Ca{u00B2}{u207A} mobilization from stores, as they cause PIP{u2082} hydrolysis and IP{u2083} production. I found in individual layer II/III pyramidal neurones a mEPSC rate of 42 {u00B1} 1 Hz. Adding noradrenaline (NA; 10 {u03BC}M; after 5') increased this rate by 50 {u00B1}...[Show more]

CollectionsOpen Access Theses
Type: Thesis (PhD)
URI: http://hdl.handle.net/1885/150867

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