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Glutathione transferase-derived compounds as potential therapeutic agents

Hewawasam, Ruwani Punyakanthi


Glutathione transferases are generally recognized for their role as antioxidant enzymes in phase II detoxification reactions. Recent studies identified a diverse range of other functions which are unrelated to detoxification. One such action is the specific inhibition of cardiac ryanodine receptor Ca{u00B2}{u207A} release channel. It is well documented that excessively active RyR2 channels are partly responsible for low store Ca{u00B2}{u207A} levels and defective Ca{u00B2}{u207A} release in...[Show more]

CollectionsOpen Access Theses
Type: Thesis (PhD)


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