Expression and function of novel members of the MS4A family
The MS4A (membrane-spanning four-domains, subfamily A) family encompasses a group of genes (MS4A1 to MS4A15 and TMEM176A and B) primarily clustered to chromosome 11q12-13. To date, the majority of MS4A family members have been reported to be expressed in cells of haematopoietic origin and to function in multimeric complexes that regulate cell activation and proliferation. The pan B cell marker, CD20 (MS4A1), was the first isolated MS4A molecule and has been shown to interact with the B cell...[Show more]
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