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The interaction of intrauterine environment and diet on the pathogenesis of Type 2 Diabetes

Madad, Leila


Introduction: Prenatal environmental factors such as intrauterine growth retardation (IDGR), as well as postnatal factors such as over-nutrition and sedentary lifestyle contribute to the development of type 2 diabetes (T2D) in predisposed individuals. The aim of this study was to determine in a rat model whether IDGR and high fat lipogenic diet interact in T2D pathogenesis. Methods: A previously described surgical model ((bilateral uterine artery ligation (BDAL)) of IDGR Sprague-Dawley rats...[Show more]

CollectionsOpen Access Theses
Date published: 2010
Type: Thesis (MPhil)
DOI: 10.25911/5d5fc88a229d8
Access Rights: Open Access


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