The interaction of intrauterine environment and diet on the pathogenesis of Type 2 Diabetes
Introduction: Prenatal environmental factors such as intrauterine growth retardation (IDGR), as well as postnatal factors such as over-nutrition and sedentary lifestyle contribute to the development of type 2 diabetes (T2D) in predisposed individuals. The aim of this study was to determine in a rat model whether IDGR and high fat lipogenic diet interact in T2D pathogenesis. Methods: A previously described surgical model ((bilateral uterine artery ligation (BDAL)) of IDGR Sprague-Dawley rats...[Show more]
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