Targeting cancer metabolism for breast cancer therapy
Cancer cells have a different metabolic profile compared to normal cells. The Warburg effect (increased aerobic glycolysis) and glutaminolysis (increased mitochondrial activity from glutamine catabolism) are well known hallmarks of cancer and are accompanied by increased lactate production, a hyperpolarised mitochondrial membrane and increased production of reactive oxygen species (ROS). Dichloroacetate (DCA) has recently been described as a novel and relatively non-toxic anticancer agent, and...[Show more]
|Collections||Open Access Theses|
|Access Rights:||Open Access|
|b25698369_Sun_Ramon Chang.pdf||39.14 MB||Adobe PDF|
Items in Open Research are protected by copyright, with all rights reserved, unless otherwise indicated.