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Targeting cancer metabolism for breast cancer therapy

Chang, Ramon Sun


Cancer cells have a different metabolic profile compared to normal cells. The Warburg effect (increased aerobic glycolysis) and glutaminolysis (increased mitochondrial activity from glutamine catabolism) are well known hallmarks of cancer and are accompanied by increased lactate production, a hyperpolarised mitochondrial membrane and increased production of reactive oxygen species (ROS). Dichloroacetate (DCA) has recently been described as a novel and relatively non-toxic anticancer agent, and...[Show more]

CollectionsOpen Access Theses
Date published: 2010
Type: Thesis (PhD)
DOI: 10.25911/5d5fcbb567697
Access Rights: Open Access


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