The impact of calcium-activated potassium channels on dendritic excitability in cortical layer 5 pyramidal neurons
Layer 5 pyramidal neurons are considered that main output units of the cortex. They receive input from all cortical layers onto their large dendritic tree. Dendritic spikes play a key role in the integration of synaptic inputs in these neurons, as they can modulate the gain of distal synaptic inputs and add another computational layer to the cell. These events are associated with calcium influx and therefore may be modulated by calcium-dependent processes such as calcium-activated potassium...[Show more]
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