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The role of the viral host response modifiers SPI-2 and N1L in mousepox pathogenesis

Rezende Melo Da Silva, Carolina


The Orthopoxvirus genus includes highly-pathogenic viruses such as variola virus and ectromelia virus (ECTV). iECDTV is a natural pathogen of mice, causing mousepox and approximately 25% of its gene products are thought to be mediators of host immune evasion that target diverse processes.such as cellular signalling, intrinsic and extrinsic cell death pathways and components of the innate immune response. I studied the role of SPI-2 and NiL genes in mousepox and for that purpose recombinant...[Show more]

CollectionsOpen Access Theses
Date published: 2011
Type: Thesis (PhD)
DOI: 10.25911/5d611990c8df9
Access Rights: Open Access


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