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Interactions between the skeletal dihydropyridine receptor {u03B2} subunit, the {u03B1}{u2081}s II-III loop and the ryanodine receptor

Karunasekara, Yamuna

Description

Excitation-contraction (EC) coupling in skeletal muscle requires a physical coupling between the dihydropyridine receptor (DHPR) Ca2+ channel in the surface membrane and the ryanodine receptor (RyRl) Ca2+ release channel in the sarcoplasmic reticulum (SR) Ca2+ store. However, the exact molecular mechanism of this interaction remains unresolved. Both the {u03B1}{u2081}s and {u03B2}{u2081}a subunits of the DHPR are essential for the skeletal BC coupling process and a central critical region of...[Show more]

CollectionsOpen Access Theses
Type: Thesis (PhD)
URI: http://hdl.handle.net/1885/150235

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