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A novel, angiogenesis-independent role for pericytes in ovarian cancer progression and metastasis

Sinha, Devbarna


Cancer-associated fibroblasts (CAFs) are a heterogeneous population of cells known for their pro-tumourigenic effect in the microenvironment of solid tumours. One of their major sources is bone marrow derived mesenchymal stem cells (BM MSCs), a population with a demonstrated ability to infiltrate the site of the tumour and engage in paracrine cross-talk with the tumour cells. However, the role of a locally resident perivascular MSC population, i.e. pericytes, has not been explored in this...[Show more]

CollectionsOpen Access Theses
Date published: 2014
Type: Thesis (PhD)
DOI: 10.25911/5d611afd2c7ce
Access Rights: Open Access


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