Uncovering the system-level regulatory architecture of gene expression in humans
Uncovering the system-level transcriptional regulatory architecture of gene expression in human has been a major focal point in modern systems biology researches. Human genes are commonly under coordinated and combinatorial transcriptional regulation mediated by a class of proteins known as transcription factors. Recent technological advancements have enabled comprehensive mapping of transcription factor binding motifs in human genome through both experimental (e.g. ChIP-seq) and computational...[Show more]
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