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Evaluating the contributions of methylation and transcription to male-biased evolution

Lindsay, Helen

Description

Male biased mutation is thought to be a consequence of mutations introduced during DNA replication. Studies of male bias have generally been restricted to an examination of bias in the total substitution rate rather than the substitution process. In this analysis, the potential contributions of germline sex differences in methylation and transcription to male biased mutation are examined via their effects on the substitution process. It is first shown that one of the post popular methods for...[Show more]

CollectionsOpen Access Theses
Type: Thesis (PhD)
URI: http://hdl.handle.net/1885/150181

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