Nuclear protein Kinase C-theta and permissive Chromatin states co-ordinate transcriptional memory responses in human T cells
Memory T cells have the selective ability to up-regulate gene transcription much more rapidly and at higher levels than naive T cells. Histone modifications are known to provide permissive Chromatin structure that facilitates this process of transcriptional memory. Protein Kinase C (PKC) family members have recently emerged as a new class of enzymes that function as both cytoplasmic signalling kinases and chromatin-modifiers that regulate gene transcription. PKC-theta is predominately expressed...[Show more]
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