Strain-specific genetic requirements for growth of vaccinia virus in culture
Poxviruses, including vaccinia virus (VACV), have linear DNA genomes, containing approximately 200 genes. Many of these genes contribute to virulence but are dispensable for replication in tissue culture. To determine whether interactions between these non-essential genes influence vaccinia virus growth in vitro, this thesis focuses on strains of VACV that lack functional copies of multiple genes. Poxvirus genomes are arranged with the highly conserved genes, which are essential for basic...[Show more]
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