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The chemoenzymatic synthesis of the lycorine framework and the synthesis of C-3-mono-alkylated oxindoles via the palladium-catalysed Ullmann cross-coupling reaction

Jones, Matthew Thomas

Description

Chapter One of this Thesis briefly describes the history and production of cis-1,2-dihydrocatechol chiral starting materials and summarises their synthetic attributes as well as providing several examples of their use in natural product synthesis. Chapter Two begins with a succinct review of the structural characteristics and biological properties of the Amaryllidaceae alkaloid ({uF02D})-lycorine and describes several established synthetic approaches to compounds of this type. Thereafter,...[Show more]

CollectionsOpen Access Theses
Type: Thesis (PhD)
URI: http://hdl.handle.net/1885/150048

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