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The chemoenzymatic synthesis of the lycorine framework and the synthesis of C-3-mono-alkylated oxindoles via the palladium-catalysed Ullmann cross-coupling reaction

Jones, Matthew Thomas


Chapter One of this Thesis briefly describes the history and production of cis-1,2-dihydrocatechol chiral starting materials and summarises their synthetic attributes as well as providing several examples of their use in natural product synthesis. Chapter Two begins with a succinct review of the structural characteristics and biological properties of the Amaryllidaceae alkaloid ({uF02D})-lycorine and describes several established synthetic approaches to compounds of this type. Thereafter,...[Show more]

CollectionsOpen Access Theses
Date published: 2013
Type: Thesis (PhD)
DOI: 10.25911/5d612016117f4
Access Rights: Open Access


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