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Understanding the mechanism that regulates LINE-1 retrotransposons in breast cancer cells

Chen, Long

Description

The human genome contains large numbers of mobile genetic elements such as repeat elements and retrotransposons. When expressed, they can cause genomic instability and induce different genetic disorders. Genomic instability is thought to be a major driving force of cancer initiation and progression. Although, it has not been completely resolved whether genomic instability is a consequence of tumour progression or an active process that drives tumour evolution, an unstable genome can be...[Show more]

CollectionsOpen Access Theses
Type: Thesis (PhD)
URI: http://hdl.handle.net/1885/150002

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