Studies on the serotype modifying O-acetyltransferase of S. flexneri : understanding its structural and functional characteristics and its role in bacterial virulence
Thirteen serotypes of S. flexneri have been recognised, all of which are capable of causing bacillary dysentery or shigellosis. Furthermore, the emergence of newer serotypes has posed additional challenges to the development of S. flexneri vaccines. One of the factors responsible for the generation of serotype diversity is an LPS O-antigen modifying, integral membrane protein known as O-acetyltransferase or Oac. Oac functions by adding an acetyl group to a specific O-antigen sugar, thus...[Show more]
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