Skip navigation
Skip navigation

Engineering enzymes for novel catalysis

Arthur, Isaac Newton

Description

Part one of this thesis outlines an attempted incorporation of a new functionality into the active site of {u03B1}-chymotrypsin through post-translational chemical modification. Model compound studies, whole protein mass spectrometry, UV spectroscopy studies, as well as cycloaddition reactions have shown that the inhibited {u03B1}-chymotrypsin undergoes an elimination reaction thereby converting the active site serine to a dehydroalanine rather than a substitution product. These results clearly...[Show more]

CollectionsOpen Access Theses
Date published: 2010
Type: Thesis (PhD)
URI: http://hdl.handle.net/1885/149862
DOI: 10.25911/5d5e787987d58
Access Rights: Open Access

Download

File Description SizeFormat Image
b28815257_Arthur_Isaac Newton.pdf37.38 MBAdobe PDFThumbnail


Items in Open Research are protected by copyright, with all rights reserved, unless otherwise indicated.

Updated:  19 May 2020/ Responsible Officer:  University Librarian/ Page Contact:  Library Systems & Web Coordinator