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Engineering enzymes for novel catalysis

Arthur, Isaac Newton


Part one of this thesis outlines an attempted incorporation of a new functionality into the active site of {u03B1}-chymotrypsin through post-translational chemical modification. Model compound studies, whole protein mass spectrometry, UV spectroscopy studies, as well as cycloaddition reactions have shown that the inhibited {u03B1}-chymotrypsin undergoes an elimination reaction thereby converting the active site serine to a dehydroalanine rather than a substitution product. These results clearly...[Show more]

CollectionsOpen Access Theses
Date published: 2010
Type: Thesis (PhD)
DOI: 10.25911/5d5e787987d58
Access Rights: Open Access


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